Product Description

Key Points

  • polyphenol complex from 100% apple
  • modulation of glycemia
  • clinically tested against markers of CV risk

What is it?

SelectSIEVE® Apple PCQ is an active ingredient based on balanced and highly standardized glycosilated polyphenols from apple.

What does it do?

SelectSIEVE® Apple PCQ components are reported to reduce intestinal glucose absorption by SGLT1/GLUT modulation (receptor affinity greater than glucose). They regulate gastrointestinal hormones at hepatic level as well as insulin secretion. They also contribute to prevent CVD by inhibiting LDL oxidation and cholesterol assimilation. They can influence the differentiation between pre-adipocytes into mature adipocytes, which are predisposed to accumulate fat.

Biological target

People affected by hyperglycemia or subjected to high risk of cardiovascular disease due to overweight.

Mechanism of action

  • Reduction of calories intake through competitive inhibition of intestinal glucose absorption due to the Phloridzin bond to the SGLT1/GLUT transporters
  • Regulation of hepatic glycemia through modulation of the G6P-translocase activity by chlorogenic acid
  • Increase of draining: improvement of blood circulation through vasculoprotector and veinotonic action of flavonoids
  • Limitation of fat storage: repression of the PPAR-γ gene (differentiation of pre-dipocytes into mature adipocytes) thus limiting fat storage in these cells

Ingredient benefits

SelectSIEVE® Apple PCQ is composed of functional polyphenols, which act in a complementary manner through different metabolic pathways.
Such polyphenols are isolated from the fruit in glycosilated form which is a guarantee of the natural source and improves their digestibility, bioavailability and stability.